CLEVELAND -- Alfredo Simon took a shutout into the sixth in his debut for Detroit and Nick Castellanos hit a two-run homer as the Tigers won their fourth straight, 8-4 over Cleveland on Friday to spoil the Indians' home opener in their remodeled ballpark.

Simon (1-0) allowed three runs and seven hits in 5 1/3 innings. The right-hander came over in an offseason trade from Cincinnati and got his first taste of what it's like to pitch for one of baseball's best lineups.

Castellanos homered in the fifth off Zach McAllister (0-1), tagged for a career-high 13 hits.

Carlos Santana had two RBIs for Cleveland, which put the tying run on deck in the ninth before Joakim Soria struck out Michael Bourn with two on for his first save.

Miguel Cabrera and Victor Martinez each had three hits and an RBI for the Tigers, who have outscored their opponents 30-5 to open the season.