Anderlecht picked up their first win in the Champions League group stage with victory over 10-man Galatasaray, but still exited the competition after Arsenal beat Borussia Dortmund.
Anderlecht came into the match third in Group D, one point better off than their opponents, and although Chancel Mbemba bagged a brace in a 2-0 win, it was not enough to keep them in the competition.
Victory at least ensured they will finish third and grab a Europa League spot.
The home side made an encouraging start as Aleksandar Mitrovic headed over in the second minute before Dennis Praet tested visiting stopper Fernando Muslera 60 seconds later.
Mbemba should have done better after he was found by a Yoeri Tielemans cross, but from close range he headed over the bar.
Just before the half-hour Muslera had to be on his toes to keep out a powerful free-kick from Tielemans.
Anderlecht kept pushing and Steven Defour smashed an effort onto the post from 25 yards out before they finally made the breakthrough moments before the break.
Frank Acheampong's cross into the box found an unmarked Mbemba, who headed back across the goalkeeper and into the net.
Silvio Proto was finally called into action in the 53rd minute as he punched Selcuk Inan's free-kick away to safety.
However normal service was resumed and Anderlecht came close to doubling their lead but Aleksandar Mitrovic's header was kept out by Muslera.
Inan saw red for a second booking before Anderlecht went two up and after keeping his side in the game for so long, Muslera will be disappointed with his contribution.
Tielemans' long-range free-kick should have been dealt with by the stopper but instead of pushing it round the post, he put the ball into the path of Mbemba who finished from close range.